What Is MPS?


The MPS is short for Mucopolysaccharidoses. Mucopolysaccharidoses is a genetic lysosomal storage disorder caused by the body’s inability to produce a certain enzyme. Normally, the body uses enzymes to break down and recycle cells after the cells die.

In affected individuals, the missing enzyme prevents the normal breakdown and recycling of cells, resulting in the storage of these cell deposits in virtually every cell of the body. As a result, cells do not perform properly and may cause progressive damage throughout the body, including the heart, bones, joints respiratory system and central nervous system.

While the disease may not be apparent at birth, signs and symptoms develop with age as more cells become damaged by the accumulation of cell deposits.

MPS IIII-A ——– Sanfiloppo A ———– Heparan N-sulfatase

MPS IIII-B——— Sanfilippo B ———— a-N- Acetylglucosaminidase

MPS III-C ——— Sanfilippo C————- Acetyl CoA: a-glycosaminide

Learn More about the disorder